Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.

@article{Guo2013InhibitionOM,
  title={Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.},
  author={X. Guo and M. Disatnik and Marie Monbureau and M. Shamloo and D. Mochly-Rosen and X. Qi},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 12},
  pages={
          5371-88
        }
}
Huntington's disease (HD) is the result of expression of a mutated Huntingtin protein (mtHtt), and is associated with a variety of cellular dysfunctions including excessive mitochondrial fission. Here, we tested whether inhibition of excessive mitochondrial fission prevents mtHtt-induced pathology. We developed a selective inhibitor (P110-TAT) of the mitochondrial fission protein dynamin-related protein 1 (DRP1). We found that P110-TAT inhibited mtHtt-induced excessive mitochondrial… Expand
216 Citations

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