Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis.

@article{Leist1999InhibitionOM,
  title={Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis.},
  author={Marcel Leist and Barbara Single and H. -H. Naumann and Eugenio Fava and Brigitte Simon and Simone K{\"u}hnle and Pierluigi Nicotera},
  journal={Experimental cell research},
  year={1999},
  volume={249 2},
  pages={396-403}
}
Under pathological conditions, the mode of cell death, apoptosis or necrosis, is relevant for the subsequent fate of the tissue. Cell demise may be shaped by endogenous mediators such as nitric oxide (NO) which interfere with subroutines of the death program. Here we show that apoptosis of Jurkat cells elicited by either staurosporine (STS) or anti-CD95 antibodies in glucose-free medium is converted to necrosis by NO donors. In the presence of NO, release of mitochondrial cytochrome c was… CONTINUE READING