Inhibition of mitochondria responsible for the anti-apoptotic effects of melatonin during ischemia-reperfusion.


OBJECTIVE To investigate a possible mechanism responsible for anti-apoptotic effects of melatonin and provide theoretical evidences for clinical therapy. METHODS Ischemia-reperfusion mediated neuronal cell injury model was constructed in cerebellar granule neurons (CGNs) by deprivation of glucose, serum and oxygen in media. After ischemia, melatonin was… (More)