Inhibition of microvascular endothelial cell apoptosis by angiopoietin-1 and the involvement of cytochrome C.

@article{Shi2006InhibitionOM,
  title={Inhibition of microvascular endothelial cell apoptosis by angiopoietin-1 and the involvement of cytochrome C.},
  author={Lian-guo Shi and Guo-ping Zhang and Hui-ming Jin},
  journal={Chinese medical journal},
  year={2006},
  volume={119 9},
  pages={725-30}
}
BACKGROUND Angiopoietin-1 (Ang-1) is an endothelial-specific growth factor that can promote angiogenesis. Studies demonstrated that Ang-1 can inhibit apoptosis of umbilical endothelial cells, but so far little is known about its effects on apoptosis of microvascular endothelial cells. With the apoptotic model of murine-cerebral-derived microvascular endothelial cells (bEnd.3) induced by serum-free culture, we attempted to clarify the molecular mechanism of bEnd.3 apoptosis, particularly its… CONTINUE READING