Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2.

@article{Zhao2009InhibitionOM,
  title={Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2.},
  author={Mingming Zhao and Seon-Yle Ko and Jin-hua Liu and Di Chen and Jianghong Zhang and Baolin Wang and Stephen E. Harris and Babatunde O. Oyajobi and Gregory R. Mundy},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 5},
  pages={1291-305}
}
Bone morphogenetic protein 2 (BMP-2) is essential for postnatal bone formation and fracture repair. By screening chemical libraries for BMP-2 mimics using a cell-based assay, we identified inhibitors of microtubule assembly as stimulators of BMP-2 transcription. These microtubule inhibitors increased osteoblast differentiation in vitro, stimulated periosteal bone formation when injected locally over murine calvaria, and enhanced trabecular bone formation when administered systemically in vivo… CONTINUE READING

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