Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia.

@article{Cuchel2007InhibitionOM,
  title={Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia.},
  author={Marina A Cuchel and Leanne T Bloedon and Philippe O. Szapary and Daniel M. Kolansky and Megan L. Wolfe and Antoine Sarkis and John S Millar and Katsunori Ikewaki and Evan S. Siegelman and Richard E. Gregg and Daniel J. Rader},
  journal={The New England journal of medicine},
  year={2007},
  volume={356 2},
  pages={148-56}
}
BACKGROUND Patients with homozygous familial hypercholesterolemia have markedly elevated cholesterol levels, which respond poorly to drug therapy, and a very high risk of premature cardiovascular disease. Inhibition of the microsomal triglyceride transfer protein may be effective in reducing cholesterol levels in these patients. METHODS We conducted a dose-escalation study to examine the safety, tolerability, and effects on lipid levels of BMS-201038, an inhibitor of the microsomal… CONTINUE READING
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