Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice

@inproceedings{Okada2015InhibitionOM,
  title={Inhibition of microRNA-214 ameliorates hepatic fibrosis and tumor incidence in platelet-derived growth factor C transgenic mice},
  author={Hikari Okada and Masao Honda and Jean S. Campbell and Kai Takegoshi and Yoshio Sakai and Taro Yamashita and Takayoshi Shirasaki and Riuta Takabatake and Mikiko Nakamura and Takuji Tanaka and Shuichi Kaneko},
  booktitle={Cancer science},
  year={2015}
}
Differentially regulated microRNA (miRNA) are associated with hepatic fibrosis; however, their potential usefulness for blocking hepatic fibrosis has not been exploited fully. We examined the expression of miRNA in the liver of a transgenic mouse model in which platelet-derived growth factor C (PDGF-C) is overexpressed (Pdgf-c Tg), resulting in hepatic fibrosis and steatosis and the eventual development of hepatocellular carcinoma (HCC). Robust induction of miR-214 correlated with fibrogenesis… CONTINUE READING
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MicroRNA-214 exerts a Cardio-protective effect by inhibition of fibrosis.

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