Inhibition of microRNA-14 contributes to actinomycin-D-induced apoptosis in the Sf9 insect cell line.


Actinomycin-D (Act-D) and other inhibitors of RNA synthesis induce extensive and rapid apoptosis in the lepidopteran insect cells. Interestingly, a similar effect is not observed in the case of protein synthesis shutdown, implying that certain RNA species may be critically required for cell survival. In order to assess whether depletion of certain anti… (More)
DOI: 10.1042/CBI20100035