Inhibition of miR-33 a / b in non-human primates raises plasma HDL and lowers VLDL triglycerides

  title={Inhibition of miR-33 a / b in non-human primates raises plasma HDL and lowers VLDL triglycerides},
  author={Katey J. Rayner and Christine Esau and Farah N. Hussain and Allison L. McDaniel and Stephanie M. Marshall and Janine M. van Gils and Tathagat Dutta Ray and Frederick J. Sheedy and Leigh Goedeke and Xueqing Liu and Oleg G. Khatsenko and Vivek Kaimal and Cynthia J. Lees and Carlos Fern{\'a}ndez-Hernando and Edward A Fisher and Ryan E Temel and Kathryn J. Moore},
Cardiovascular disease remains the leading cause of mortality in westernized countries, despite optimum medical therapy to reduce the levels of low-density lipoprotein (LDL)-associated cholesterol. The pursuit of novel therapies to target the residual risk has focused on raising the levels of high-density lipoprotein (HDL)associated cholesterol in order to exploit its atheroprotective effects. MicroRNAs (miRNAs) have emerged as important posttranscriptional regulators of lipid metabolism and… CONTINUE READING
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MicroRNA - 33 and theSREBPhostgenes cooperate to control cholesterol homeostasis

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