Inhibition of miR-203 Reduces Spontaneous Recurrent Seizures in Mice

  title={Inhibition of miR-203 Reduces Spontaneous Recurrent Seizures in Mice},
  author={Sang Kun Lee and Daejong Jeon and Kon Chu and Keun-Hwa Jung and J Moon and Junsang Sunwoo and Dong-Kyu Park and Hyunwoo Yang and Ji-hyun Park and Manho Kim and J N Roh},
  journal={Molecular Neurobiology},
Inhibitory synaptic receptors are dysfunctional in epileptic brains, and agents that selectively target these receptors may be effective for the treatment of epilepsy. MicroRNAs interfere with the translation of target genes, including various synaptic proteins. Here, we show that miR-203 regulates glycine receptor-β (Glrb) in epilepsy models. miR-203 is upregulated in the hippocampus of epileptic mice and human epileptic brains and is predicted to target inhibitory synaptic receptors… CONTINUE READING
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