Inhibition of miR-15 protects against cardiac ischemic injury.

  title={Inhibition of miR-15 protects against cardiac ischemic injury.},
  author={Thomas G Hullinger and Rusty L. Montgomery and Anita G. Seto and Brent A Dickinson and Hillary M. Semus and Joshua M. Lynch and Christina M Dalby and Kathryn Robinson and Christianna Stack and Paul A Latimer and Joshua M Hare and Eric N Olson and Eva van Rooij},
  journal={Circulation research},
  volume={110 1},
RATIONALE Myocardial infarction (MI) is a leading cause of death worldwide. Because endogenous cardiac repair mechanisms are not sufficient for meaningful tissue regeneration, MI results in loss of cardiac tissue and detrimental remodeling events. MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression in a sequence dependent manner. Our previous data indicate that miRNAs are dysregulated in response to ischemic injury of the heart and actively contribute to cardiac… CONTINUE READING
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