Inhibition of miR-143 during ischemia cerebral injury protects neurones through recovery of the hexokinase 2-mediated glucose uptake.

@article{Zeng2017InhibitionOM,
  title={Inhibition of miR-143 during ischemia cerebral injury protects neurones through recovery of the hexokinase 2-mediated glucose uptake.},
  author={Xianzhu Zeng and Na Liu and Jing Zhang and Lei Wang and Zhecheng Zhang and Ju Zhu and Qian Li and Yuwen Wang},
  journal={Bioscience reports},
  year={2017},
  volume={37 4}
}
Ischemic stroke, a major cause of death, is caused by occlusion of a blood vessel, resulting in significant reduction in regional cerebral blood flow. MiRNAs are a family of short noncoding RNAs (18-22 nts) and bind the 3'-UTR of their target genes to suppress the gene expression post-transcriptionally. In the present study, we report that miR-143 is down-regulated in rat neurones but highly expressed in astrocytes. In vivo middle cerebral artery occlusion (MCAO) and ex vivo oxygen-glucose… CONTINUE READING
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