Inhibition of metallo-beta-lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid.

@article{Payne1997InhibitionOM,
  title={Inhibition of metallo-beta-lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid.},
  author={David J Payne and John H Bateson and B C Gasson and T Khushi and Douglas Proctor and Stewart C Pearson and Ralph Reid},
  journal={FEMS microbiology letters},
  year={1997},
  volume={157 1},
  pages={171-5}
}
A series of mercaptophenylacetic acid thiol esters bearing a phenyl substituent adjacent to the carboxylic acid function has been shown to be inhibitors of metallo-beta-lactamases. The inhibition of the Bacteroides fragilis CfiA and Bacillus cereus II metallo-beta-lactamases was Zn2- dependent, greater inhibition being observed at 1 microM ZnSO4 than at 100… CONTINUE READING