Inhibition of mesodermal fate by Xenopus HNF3beta/FoxA2.

  title={Inhibition of mesodermal fate by Xenopus HNF3beta/FoxA2.},
  author={Crystal Suri and Tomomi Haremaki and Daniel C Weinstein},
  journal={Developmental biology},
  volume={265 1},
The winged-helix transcription factor HNF3beta/FoxA2 is expressed in embryonic organizing centers of the gastrulating mouse, frog, fish, and chick. In the mouse, HNF3beta is required for the formation of the mammalian node and notochord, and can induce ectopic floor plate formation when misexpressed in the developing neural tube; HNF3beta expression in the extraembryonic endoderm is also necessary for the proper morphogenesis of the mammalian primitive streak. In the frog Xenopus laevis… CONTINUE READING


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