Inhibition of memory consolidation after active avoidance conditioning by antisense intervention with ependymin gene expression.

@article{Schmidt1995InhibitionOM,
  title={Inhibition of memory consolidation after active avoidance conditioning by antisense intervention with ependymin gene expression.},
  author={Reinhard Schmidt and Wolfgang Brysch and S. Lynn Rother and Karl Hermann Schlingensiepen},
  journal={Journal of neurochemistry},
  year={1995},
  volume={65 4},
  pages={1465-71}
}
A rapid increase in ependymin mRNA expression demonstrated by semiquantitative in situ hybridization after avoidance conditioning on goldfish suggested a molecular demand for newly synthesized ependymin translation product. To inhibit de novo synthesis of ependymin molecules without interference with preexisting ones, 18 mer anti-ependymin mRNA-phosphorothioate oligodeoxynucleotides (S-ODNs) were injected into the perimeningeal brain fluid before active avoidance training. S-ODN-injected… CONTINUE READING
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