Inhibition of melanoma cells tumorigenicity by the snake venom toxin jararhagin.

  title={Inhibition of melanoma cells tumorigenicity by the snake venom toxin jararhagin.},
  author={M{\'a}rio C{\'e}sar Corr{\^e}a and Durvanei Augusto Maria and Ana Maria Moura-da-Silva and Kazumi F Pizzocaro and Itamar Romano Garcia Ruiz},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={40 6},
Skmel-28 human melanoma cells were treated with jararhagin (Jara), a metalloproteinase disintegrin isolated from Bothrops jararaca snake venom, and Jari (Jara with the catalytic domain inactivated). Following treatments, monolayer cells lost cytoplasmic expansions acquiring round shapes, detached and formed cell clusters in suspension. Cytotoxicity effect of Jari was dramatically increased at concentrations higher than 0.4 microM, whereas cell adhesion responses did not differ significantly… CONTINUE READING


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