Inhibition of melanin content by Punicalagins in the super fruit pomegranate (Punica granatum).

@article{Rana2013InhibitionOM,
  title={Inhibition of melanin content by Punicalagins in the super fruit pomegranate (Punica granatum).},
  author={Jatinder Rana and Ganesh Diwakar and Lisa L. Saito and Jeffrey D. Scholten and Timothy Craig Mulder},
  journal={Journal of cosmetic science},
  year={2013},
  volume={64 6},
  pages={
          445-53
        }
}
Current efforts to develop effective skin lightening products through the inhibition of melanin production have focused on compounds that inhibit the function and activity of tyrosinase, the rate-limiting enzyme in the melanin biosynthesis pathway. Synthetic tyrosinase inhibitors, such as hydroquinone, kojic acid, and arbutin, have been reported to cause skin irritation or acute dermatitis, raising concerns about the safety of these compounds. As a result, there is a need for safe natural… CONTINUE READING