Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade

  title={Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade},
  author={Zhao Xu and Yong Ho Kim and Sangsu Bang and Yi Zhang and Temugin Berta and Fan Wang and Seog Bae Oh and Rongrong Ji},
  journal={Nature Medicine},
Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation, represents a cardinal feature of neuropathic pain. Blockade or ablation of high-threshold, small-diameter unmyelinated group C nerve fibers (C-fibers) has limited effects on mechanical allodynia. Although large, myelinated group A fibers, in particular Aβ-fibers, have previously been implicated in mechanical allodynia, an A-fiber–selective pharmacological blocker is still lacking. Here we report a new… CONTINUE READING
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