Inhibition of matrix metalloproteinases-2 and -9 prevents cognitive impairment induced by pneumococcal meningitis in Wistar rats.

@article{Barichello2014InhibitionOM,
  title={Inhibition of matrix metalloproteinases-2 and -9 prevents cognitive impairment induced by pneumococcal meningitis in Wistar rats.},
  author={Tatiana Barichello and Jaqueline S Generoso and Cleonice M. Michelon and Lutiana Roque Sim{\~o}es and Samuel Galv{\~a}o Elias and Franciele Vuolo and Clarissa Martinelli Comim and Felipe Dal-Pizzol and Jo{\~a}o Quevedo},
  journal={Experimental biology and medicine},
  year={2014},
  volume={239 2},
  pages={
          225-31
        }
}
Pneumococcal meningitis is a relevant clinical disease characterized by an intense inflammatory reaction into the subarachnoid and ventricular spaces, leading to blood-brain barrier breakdown, hearing loss, and cognitive impairment. Matrix metalloproteinases (MMPs) are capable of degrading components of the basal laminin, thus contributing to BBB damage and neuronal injury. In the present study, we evaluated the effects of MMP-2, MMP-9, and MMP-2/9 inhibitors on BBB integrity, learning, and… CONTINUE READING
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