Inhibition of matrix metalloproteinase-9 attenuates acute small-for-size liver graft injury in rats.

Abstract

Ischemia/reperfusion (I/R) and portal hypertension have been implicated in small-for-size liver graft dysfunction. Matrix metalloproteinases-2 and -9 (MMP-2/9) are critically proposed to involve in hepatic I/R injury and activated by hemodynamic force. We hypothesized that MMP-2/9 overexpression played a crucial role in acute graft injury following small… (More)
DOI: 10.1111/j.1600-6143.2009.02993.x

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