Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells.

@article{Ordez2014InhibitionOM,
  title={Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells.},
  author={Raquel Ord{\'o}{\~n}ez and Sara Carbajo-Pescador and N{\'e}stor Prieto-Dom{\'i}nguez and Andr{\'e}s Garc{\'i}a-Palomo and Javier Gonz{\'a}lez-Gallego and Jos{\'e} Lu{\'i}s Mauriz},
  journal={Journal of pineal research},
  year={2014},
  volume={56 1},
  pages={20-30}
}
Hepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide because of its high incidence and its metastatic potential. Extracellular matrix degradation by matrix metalloproteinases (MMPs) has been connected with cancer cell invasion, and it has been suggested that inhibition of MMPs by synthetic and natural inhibitors may be of great importance in the HCC therapies. Melatonin, the main product of the pineal gland, exerts antiproliferative, proapoptotic, and antiangiogenic… CONTINUE READING
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