Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration.

  title={Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration.},
  author={Kevin Zarrabi and Antoine Dufour and Jian Li and Cem Kuscu and Ashleigh E Pulkoski-Gross and Jizu Zhi and Youjun Hu and Nicole S Sampson and Stanley Zucker and Jian Cao},
  journal={The Journal of biological chemistry},
  volume={286 38},
Matrix metalloproteinases (MMPs) have been shown to be key players in both extracellular matrix remodeling and cell migration during cancer metastasis. MMP-14, a membrane-anchored MMP, in particular, is closely associated with these processes. The hemopexin (PEX) domain of MMP-14 has been proposed as the modulating region involved in the molecular cross-talk that initiates cell migration through homodimerization of MMP-14 as well as heterodimerization with the cell surface adhesion molecule… CONTINUE READING
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