Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) Cells by isoflavones

  title={Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) Cells by isoflavones},
  author={Shilpa Puli and James C. K. Lai and Alok Bhushan},
  journal={Journal of Neuro-Oncology},
Glioblastoma multiforme is a primary brain tumor associated with extensive invasion into surrounding brain tissue. Matrix metalloproteinases (MMPs) and urokinase plasminogen activation (uPA) system are shown to be involved in tumor invasion as they help in degradation of extracellular matrix (ECM) proteins and thus assist in the movement of cells. MMP-2 and 9 were shown to be upregulated in gliomas, suggesting their involvement in invasion. Genistein and biochanin A are isoflavones commonly… CONTINUE READING


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