Inhibition of mammary tumorigenesis in carcinogen-treated Lewis rats by suppression of prolactin secretion.

@article{Welsch1979InhibitionOM,
  title={Inhibition of mammary tumorigenesis in carcinogen-treated Lewis rats by suppression of prolactin secretion.},
  author={Clifford W. Welsch and C. Kice Brown and M Goodrich-Smith and Joeri Van and Barry Denenberg and Timothy Mark Anderson and Christopher L. Brooks},
  journal={Journal of the National Cancer Institute},
  year={1979},
  volume={63 5},
  pages={1211-4}
}
One hundred sixty-eight female Lewis rats were treated intragastrically with 10 mg 7,12-dimethylbenz[a]anthracene at 56 and 63 days of age. Pituitary prolactin secretion was suppressed in one-half of these rats by daily sc administrations of 2-bromoergocryptine mesylate (CB-154; 0.4 mg/100 g body wt) from 29 to 90 days of age (series 1) and from 90 to 140 days of age (series 2). Treatment with CB-154 was initiated prior to the onset of palpable mammary carcinomas. Control rats were given… CONTINUE READING
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