Inhibition of mammary gland differentiation in vitro by 5-bromo-2'-deoxyuridine.


Mammary epithelial cells in organ culture incorporate 5-bromo-2’-deoxyuridine (BUdR) into DNA during a single cycle of DNA replication. The specific milk proteins, casein and oc-lactalbumin, are induced by prolactin in control mammary cells, but the induction of these proteins is markedly inhibited in cells which contain BUdR-DNA. This is a selective effect… (More)

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