Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants.

@article{Locatelli2005InhibitionOM,
  title={Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants.},
  author={Giada Aurora Locatelli and Monica Savio and Luca Forti and Igor V. Shevelev and Kristijan Ramadan and Lucia Anna Stivala and Vanio Vannini and Ulrich H{\"u}bscher and Silvio Spadari and Giovanni Maga},
  journal={The Biochemical journal},
  year={2005},
  volume={389 Pt 2},
  pages={259-68}
}
Resveratrol, a natural compound found in many dietary plants and in red wine, plays an important role in the prevention of many human pathological processes, including inflammation, atherosclerosis and carcinogenesis. We have shown that the antiproliferative activity of resveratrol correlated with its ability to inhibit the replicative pols (DNA polymerases) alpha and delta in vitro [Stivala, Savio, Carafoli, Perucca, Bianchi, Maga, Forti, Pagnoni, Albini, Prosperi and Vannini (2001) J. Biol… CONTINUE READING