Inhibition of malic enzyme by S-oxalylglutathione, a probable in vivo effector.

@article{Harris1987InhibitionOM,
  title={Inhibition of malic enzyme by S-oxalylglutathione, a probable in vivo effector.},
  author={Robin K. Harris and Gary Hamilton},
  journal={Biochemistry},
  year={1987},
  volume={26 1},
  pages={1-5}
}
Various oxalyl thiol esters (RSCOCOO-), especially S-oxalylglutathione (GS-Ox), were found to be very effective inhibitors of chicken liver malic enzyme. When the conditions are similar to those encountered physiologically [high reduced nicotinamide adenine dinucleotide phosphate (NADPH) concentrations], inhibition is detectable with less than 1 microM concentrations of GS-Ox. The amount of inhibition is not reversed by excess glutathione, thus indicating that it is not due to oxalyl transfer… CONTINUE READING