Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2.

@article{Traynor1999InhibitionOM,
  title={Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2.},
  author={T. Traynor and A. Smart and J. Briggs and J. Schnermann},
  journal={The American journal of physiology},
  year={1999},
  volume={277 5},
  pages={
          F706-10
        }
}
Previous results from our laboratory have shown that in the isolated perfused juxtaglomerular apparatus, nonselective inhibitors of cyclooxygenase (COX) activity prevent the stimulation of renin secretion by a reduction in luminal NaCl concentration at the macula densa. The present studies were performed to examine which COX isoform is involved in NaCl-dependent renin secretion. In the absence of COX inhibitors, a reduction in luminal NaCl (from Na 141/Cl 120 mM to Na 26/Cl 7 mM) caused an… Expand
Role of renocortical cyclooxygenase-2 for renal vascular resistance and macula densa control of renin secretion.
TLDR
In states of increased renocortical expression of COX-2, overall renal vascular resistance and the macula densa control of renin secretion become dependent on COx-2-derived prostanoids. Expand
Preserved macula densa-dependent renin secretion in A1 adenosine receptor knockout mice.
TLDR
The data indicate that the A(1)AR is not indispensable in macula densa control of the renin system, whereas they are consistent with the concept of a tonic inhibitory role of the A(-/-)AR in the renIn system. Expand
Furosemide stimulates macula densa cyclooxygenase-2 expression in rats.
TLDR
It is suggested that inhibition of salt transport in the loop of Henle, but not in the distal tubule, causes a selective stimulation of COX-2 expression in the macula densa region, which links tubular salt transport rate with glomerular filtration rate and renin secretion. Expand
Role of macula densa cyclooxygenase-2 in renovascular hypertension.
TLDR
It is concluded that inhibition of COX-2 in established renovascular hypertension does not affect renin synthesis or release, and either COx-2 is not necessary for the macul densa mechanism or the macula densa is not important for maintaining high renin in renov vascular hypertension. Expand
Tubular control of renin synthesis and secretion
TLDR
Experimental evidence indicates an inverse relation between luminal NaCl concentration and renin secretion, and at least some of the available evidence is consistent with an important suppressive effect of adenosine at higher salt concentrations. Expand
Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride.
TLDR
Results suggest that reduced extracellular chloride leads to increased COX-2 expression, which may be mediated by activation of a p38-dependent signaling pathway. Expand
Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1.
TLDR
This study provides definitive evidence that metabolites of COX-2 rather thanCOX-1 mediate ACEI-induced renin increases and suggests involvement of prostaglandin E(2) receptor subtype 4 and/or prostacyclin receptor (IP). Expand
Low Chloride Stimulation of Prostaglandin E2Release and Cyclooxygenase-2 Expression in a Mouse Macula Densa Cell Line*
TLDR
It is concluded that low chloride stimulates PGE2 release and COX-2 expression in MMDD1 cells through activation of MAP kinases. Expand
General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system.
TLDR
A general inhibitory effect of the renin-angiotensin system on renocortical COX-2 expression is suggested, suggesting that renin and cyclooxygenase-2expression in the kidney cortex are regulated in parallel. Expand
Inhibition of nNOS expression in the macula densa by COX-2-derived prostaglandin E(2).
TLDR
Findings reveal that the absence of either COX-2 or nNOS is associated with suppressed renin secretion and the inhibitory effect of PGE(2) on nN OS mRNA expression indicates a novel interaction between NO and prostaglandin-mediated pathways of renin regulation. Expand
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