Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2.

@article{Traynor1999InhibitionOM,
  title={Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2.},
  author={T. Traynor and A. Smart and J. Briggs and J. Schnermann},
  journal={American journal of physiology. Renal physiology},
  year={1999},
  volume={277 5},
  pages={F706-F710}
}
Previous results from our laboratory have shown that in the isolated perfused juxtaglomerular apparatus, nonselective inhibitors of cyclooxygenase (COX) activity prevent the stimulation of renin secretion by a reduction in luminal NaCl concentration at the macula densa. The present studies were performed to examine which COX isoform is involved in NaCl-dependent renin secretion. In the absence of COX inhibitors, a reduction in luminal NaCl (from Na 141/Cl 120 mM to Na 26/Cl 7 mM) caused an… Expand
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