Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2.

  title={Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2.},
  author={Timothy R. Traynor and Ann M Smart and Josephine P. Briggs and Jurgen Schnermann},
  journal={American journal of physiology. Renal physiology},
  volume={277 5},
Previous results from our laboratory have shown that in the isolated perfused juxtaglomerular apparatus, nonselective inhibitors of cyclooxygenase (COX) activity prevent the stimulation of renin secretion by a reduction in luminal NaCl concentration at the macula densa. The present studies were performed to examine which COX isoform is involved in NaCl-dependent renin secretion. In the absence of COX inhibitors, a reduction in luminal NaCl (from Na 141/Cl 120 mM to Na 26/Cl 7 mM) caused an… 
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Role of prostaglandins in renin secretion in the isolated kidney.

  • S. Linas
  • Medicine, Biology
    The American journal of physiology
  • 1984
The isolated perfused rat kidney was used to study the role of PG as a mediator of renin secretion when extracellular calcium was decreased and after activation of each of the intrarenal receptors.

Effect of prostanoids on renin release from rabbit afferent arterioles with and without macula densa.

The hypothesis that prostaglandin (PG) I2 and/or its metabolite(s), which are synthesized in the afferent arteriole (AF), stimulate renin release by acting directly on the AF while PGE2 stimulates reninRelease indirectly via the macula densa is tested.

Direct demonstration of macula densa-mediated renin secretion.

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Coordinate expression of cyclooxygenase-2 and renin in the rat kidney in renovascular hypertension.

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Juxtaglomerular cell complex in the regulation of renal salt excretion.

  • J. Schnermann
  • Medicine, Biology
    The American journal of physiology
  • 1998
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Cyclooxygenase-2 mediates increased renal renin content induced by low-sodium diet.

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Prostaglandin in renin release during sodium deprivation.

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