Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

@inproceedings{Spilman2010InhibitionOM,
  title={Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease},
  author={Patricia Spilman and Natalia Podlutskaya and Matthew J. Hart and Jayanta Debnath and Olivia F. Gorostiza and Dale E. Bredesen and Arlan Richardson and Randy Strong and Ver{\'o}nica Galv{\'a}n},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Reduced TOR signaling has been shown to significantly increase lifespan in a variety of organisms [1], [2], [3], [4]. It was recently demonstrated that long-term treatment with rapamycin, an inhibitor of the mTOR pathway[5], or ablation of the mTOR target p70S6K[6] extends lifespan in mice, possibly by delaying aging. Whether inhibition of the mTOR pathway would delay or prevent age-associated disease such as AD remained to be determined. METHODOLOGY/PRINCIPAL FINDINGS We used… CONTINUE READING

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