Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats

@article{Balschun2002InhibitionOM,
  title={Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats},
  author={Detlef Balschun and Wolfram Wetzel},
  journal={Pharmacology Biochemistry and Behavior},
  year={2002},
  volume={73},
  pages={375-380}
}
Particular subtypes of metabotropic glutamate receptors (mGluRs) have been shown to be specifically involved in certain types of long-term synaptic plasticity and learning. We examined whether inhibition of mGluR5 by the specific noncompetitive antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) has any functional consequences on long-term potentiation in the dentate gyrus in vivo and on learning of a spatial alternation task. Intracerebroventricular application of 13.8 microg MPEP 30 min… CONTINUE READING
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