Inhibition of mCD14 inhibits TNFα secretion and NO production in RAW264.7 cells stimulated by Brucella melitensis infection.

@article{Lei2012InhibitionOM,
  title={Inhibition of mCD14 inhibits TNFα secretion and NO production in RAW264.7 cells stimulated by Brucella melitensis infection.},
  author={Ming Lei and Li Du and Hanwei Jiao and Ying Cheng and Donglin Zhang and Yongchang Hao and Gangshan Li and Wei Qiu and Quanshui Fan and Chengyao Li and Chuanfu Chen and Fengyang Wang},
  journal={Veterinary microbiology},
  year={2012},
  volume={160 3-4},
  pages={362-8}
}
Brucellosis, caused by Brucella spp., is an important disease affecting not only human health, but also a number of animal species around the world. A receptor for LPS of Brucella and important innate immune molecule, CD14, has been implicated in the initiation of the inflammatory response to sepsis. Evidence indicates that upstream inhibition of the LPS initiated inflammatory pathway is an effective therapeutic approach for attenuating damaging immune activation. The aim of this study was to… CONTINUE READING