Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection.

@article{Wei2005InhibitionOL,
  title={Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection.},
  author={Bangdong L Wei and Paul W Denton and Eduardo O'Neill and Tianci Luo and John L. Foster and Jacquelyn Garcia},
  journal={Journal of virology},
  year={2005},
  volume={79 9},
  pages={
          5705-12
        }
}
We previously reported that inhibition of endosomal/lysosomal function can dramatically enhance human immunodeficiency virus type 1 (HIV-1) infectivity, suggesting that under these conditions productive HIV-1 infection can occur via the endocytic pathway. Here we further examined this effect with bafilomycin A1 (BFLA-1) and show that this enhancement of infectivity extends to all HIV-1 isolates tested regardless of coreceptor usage. However, isolate-specific differences were observed in the… CONTINUE READING

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