Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice

@inproceedings{Kritikou2016InhibitionOL,
  title={Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice},
  author={Eva Kritikou and Gijs H. M. van Puijvelde and Thomas van der Heijden and Peter J. van Santbrink and Maarten Swart and Frank H. Schaftenaar and Mara J. Kr{\"o}ner and J. J. W. Kuiper and Ilze Bot},
  booktitle={Scientific reports},
  year={2016}
}
Lysophosphatidic acid (LPA) is a natural lysophospholipid present at high concentrations within lipid-rich atherosclerotic plaques. Upon local accumulation in the damaged vessels, LPA can act as a potent activator for various types of immune cells through its specific membrane receptors LPA1/3. LPA elicits chemotactic, pro-inflammatory and apoptotic effects that lead to atherosclerotic plaque progression. In this study we aimed to inhibit LPA signaling by means of LPA1/3 antagonism using the… CONTINUE READING
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