Inhibition of lymphocyte-mediated antibacterial activity by human seminal plasma.

  title={Inhibition of lymphocyte-mediated antibacterial activity by human seminal plasma.},
  author={Claudio De Simone and Giuseppe Caretto and P. P. Grassi and Vito Covelli and Andrea Lenzi and Salvatore Antonaci and Emilio Jirillo},
  journal={American journal of reproductive immunology and microbiology : AJRIM},
  volume={17 1},
Seminal plasma displays a suppressive function on many immunological responses. In light of recent findings on the antibacterial activity mediated by different lymphocyte subsets, we have assessed the effect of male inhibitory material (MIM) in this system. Results provide evidence that MIM pretreatment of peripheral blood lymphocytes (PBL) leads to a significant inhibition of antibacterial activity against Salmonella typhi and S. minnesota R345 (Rb). Both CD4+ and CD8+ cell-mediated activities… 
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Effect of Boar Seminal Immunosuppressive Component on Humoral Immune Response in Mice
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Immunosuppressive effect induced by intraperitoneal and rectal administration of boar seminal immunosuppressive factor.
The findings indicate that rectal deposition of semen may compromise some aspects of the immune system and may be an important cofactor in the development of viral or bacterial infections among homosexual men.
Pathogenetical and Clinical Aspects of Antisperm Immunity
Recent findings suggest that Fas ligand (FasL), expressed on the surface of Sertoli cells, is involved in maintaining the immune privilege by preventing activated lymphocytes from infiltrating the testis, and has been proposed to play a role in the prevention of lymphocytes responses against sperm autoantigens in the male genital tract.
Inhibition of bacterial and boar epididymal sperm immunogenicity by boar seminal immunosuppressive component in mice.
Intravenous deposition of the immunosuppressive component, isolated from boar seminal vesicle secretion, led to suppression of primary and secondary antibody response to boar epididymal spermatozoa
Mechanisms and effects of male genital tract infection on sperm quality and fertilizing potential: the andrologist's viewpoint.
Clinicians should stimulate clinicians to place more emphasis on the prevention of infection-related infertility than on its treatment, as the latter is often unsuccessful.
Male infertility: Evaluation of human sperm function and its clinical application
  • A. Lenzi
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Immunosuppressive activity of human seminal plasma. I. Inhibition of in vitro lymphocyte activation.
Observations support the concept that a local immune response against sperm in the female reproductive tract is actively suppressed by a component in seminal plasma.
The relationship between the immunosuppressive and cytotoxic effects of human seminal plasma.
  • R. Allen, T. Roberts
  • Biology, Medicine
    American journal of reproductive immunology and microbiology : AJRIM
  • 1986
It is demonstrated that the inhibition of response to mitogens shown by murine lymphocytes in the presence of whole human seminal plasma can be attributed largely to an effect of seminal components on lymphocyte viability.
Suppression of natural and activated human antitumour cytotoxicity by human seminal plasma.
The influence of human seminal plasma (SP) and whole semen (S) on the expression of natural cytotoxicity by human peripheral blood mononuclear cells (PBMNC) was examined and the biological significance of SP as an inhibitor of immune function under experimentally defined conditions is discussed.
Human seminal plasma inhibition of complement.
The seminal plasma factor which inhibited complement was of low molecular weight and is likely that the seminal plasma complement inhibitor is a protease inhibitor acting singly or in combination.
Relationship between immune system and gram negative bacteria. I. Spontaneous binding of smooth and rough Salmonella to human peripheral blood lymphocytes.
Using a panel of monoclonal antibodies to lymphocyte surface antigens, S- and R-Salmonella bacteria bind to T lymphocytes (preferentially T8+ cells), while few B cells are coated by bacteria.
Natural anti-bacterial activity against Salmonella typhi by human T4+ lymphocytes armed with IgA antibodies.
It is suggested that NA activity by human cells might be a mechanism of defense against infections, acting as antibody-dependent cellular cytotoxicity expressed by T4+ lymphocytes coated with preexisting anti-Salmonella IgA antibodies.
Immunosuppressive effects of mouse seminal plasma components in vivo and in vitro.
Mouse seminal plasma (SP), a mixture of aqueous extracts of prostate, seminal vesicle, and epididymis, exerts potent immunosuppressive effects in vivo; these factors may serve to protect sperm from immunologic damage and prevent sensitization of females to sperm antigens after insemination.