Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the (NZB x NZW)F1 mouse.

@article{Werwitzke2005InhibitionOL,
  title={Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the (NZB x NZW)F1 mouse.},
  author={Sonja Werwitzke and D Trick and Kenji Kamino and Torsten Matthias and Katja Kniesch and Brigitte Schlegelberger and Reinhold Ernst Schmidt and Torsten Witte},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 11},
  pages={
          3629-38
        }
}
OBJECTIVE In systemic lupus erythematosus (SLE), immune complexes (ICs) containing pathogenic IgG anti-double-stranded DNA (anti-dsDNA) autoantibodies are deposited in renal capillaries and initiate glomerulonephritis (GN) by the activation of complement and effector cells. In contrast, it has been demonstrated that the presence of IgM anti-dsDNA antibodies correlates negatively with the development of GN in SLE. The aim of this study was to determine whether anti-dsDNA antibodies of the IgM… CONTINUE READING
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