Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways.

@article{Hanai2012InhibitionOL,
  title={Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways.},
  author={Jun-ichi Hanai and Nathaniel C. Doro and Atsuo T. Sasaki and Shigeyasu Kobayashi and Lewis C. Cantley and P. C. C. Seth and Vikas P Sukhatme},
  journal={Journal of cellular physiology},
  year={2012},
  volume={227 4},
  pages={
          1709-20
        }
}
ATP citrate lyase (ACL) catalyzes the conversion of cytosolic citrate to acetyl-CoA and oxaloacetate. A definitive role for ACL in tumorigenesis has emerged from ACL RNAi and chemical inhibitor studies, showing that ACL inhibition limits tumor cell proliferation and survival and induces differentiation in vitro. In vivo, it reduces tumor growth leading to a cytostatic effect and induces differentiation. However, the underlying molecular mechanisms are poorly understood and agents that could… CONTINUE READING
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