Inhibition of local estrogen synthesis in the hippocampus impairs hippocampal memory consolidation in ovariectomized female mice.

@article{Tuscher2016InhibitionOL,
  title={Inhibition of local estrogen synthesis in the hippocampus impairs hippocampal memory consolidation in ovariectomized female mice.},
  author={Jennifer J. Tuscher and Julia S Szinte and Joseph R Starrett and Amanda A Krentzel and Ashley M. Fortress and Luke Remage-Healey and Karyn M. Frick},
  journal={Hormones and behavior},
  year={2016},
  volume={83},
  pages={60-67}
}
The potent estrogen 17β-Estradiol (E2) plays a critical role in mediating hippocampal function, yet the precise mechanisms through which E2 enhances hippocampal memory remain unclear. In young adult female rodents, the beneficial effects of E2 on memory are generally attributed to ovarian-synthesized E2. However, E2 is also synthesized in the adult brain in numerous species, where it regulates synaptic plasticity and is synthesized in response to experiences such as exposure to females or… CONTINUE READING