Inhibition of local aldosterone by eplerenone reduces renal structural damage in a novel model of chronic cyclosporine A nephrotoxicity.

@article{Sun2015InhibitionOL,
  title={Inhibition of local aldosterone by eplerenone reduces renal structural damage in a novel model of chronic cyclosporine A nephrotoxicity.},
  author={Qiao-ling Sun and Meng Li and Hong-liang Rui and Yi-Pu Chen},
  journal={Journal of the renin-angiotensin-aldosterone system : JRAAS},
  year={2015},
  volume={16 2},
  pages={301-10}
}
BACKGROUND AND OBJECTIVE The fact that mineralocorticoid receptor antagonists reduce structural and functional alterations induced by cyclosporine A (CsA) indicates that aldosterone plays a key role in chronic CsA nephrotoxicity. We and other researchers have reported local renal aldosterone synthesis. To investigate local renal aldosterone's role in chronic CsA nephrotoxicity, we evaluated the effect of eplerenone (Epl) on renal structural damage and renal dysfunction in adrenalectomized (ADX… CONTINUE READING