Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium.

Abstract

Three sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from Xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (IC(50) values: 0.47, 11.2, 136.5 microM, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-kappaB through the inhibition… (More)
DOI: 10.1016/j.bmcl.2007.12.076

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@article{Yoon2008InhibitionOL, title={Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium.}, author={Jeong Hoon Yoon and Hyo Jin Lim and Hwa Jin Lee and Hee-Doo Kim and Raok Jeon and Jae Ha Ryu}, journal={Bioorganic & medicinal chemistry letters}, year={2008}, volume={18 6}, pages={2179-82} }