Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide and cyclooxygenase-2 by chiisanoside via suppression of nuclear factor-kappaB activation in RAW 264.7 macrophage cells.

@article{Won2005InhibitionOL,
  title={Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide and cyclooxygenase-2 by chiisanoside via suppression of nuclear factor-kappaB activation in RAW 264.7 macrophage cells.},
  author={Jong-Heon Won and Sang-yong Park and Sang-Gil Nam and H. K. Park and Jong-Won Choi and K. -J. Lee},
  journal={Biological & pharmaceutical bulletin},
  year={2005},
  volume={28 10},
  pages={1919-24}
}
In the present study, the effects of several triterpenes isolated from the leaves of Acanthopanax chiisanensis (Araliaceae), namely, chiisanoside, isochiisanoside, 22-hydroxychiisanoside and chiisanogenin (the aglycone of chiisanoside) were evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by the RAW 264… CONTINUE READING