Inhibition of lipid peroxidation in CNS trauma.

  title={Inhibition of lipid peroxidation in CNS trauma.},
  author={Edward D. Hall},
  journal={Journal of neurotrauma},
  volume={8 Suppl 1},
  pages={S31-40; discussion S41}
It is believed that the key mechanism of protection of the injured spinal cord by methylprednisolone (MP) is the inhibition of posttraumatic lipid peroxidation. Large, i.v. bolus doses are required to achieve this effect, but the biphasic dose-response curve limits the dose size to approximately 30 mg/kg. The mechanism for the reversed effect at higher concentrations is believed currently to be membrane disruption. Early treatment is required because injury mediated by lipid peroxidation is… CONTINUE READING