Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability of a novel dietary fatty acid formulation in healthy adult subjects.

@article{Surette2003InhibitionOL,
  title={Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability of a novel dietary fatty acid formulation in healthy adult subjects.},
  author={Marc E. Surette and Iphigenia L Koumenis and Michelle B. Edens and Kenneth M. Tramposch and Floyd H. Chilton},
  journal={Clinical therapeutics},
  year={2003},
  volume={25 3},
  pages={948-71}
}
BACKGROUND Numerous studies have explored dietary-management strategies for decreasing leukotriene synthesis by inflammatory cells through supplementation with polyunsaturated fatty acids such as gamma-linolenic acid (GLA) and eicosapentaenoic acid (EPA). OBJECTIVES This study sought to determine the optimal daily intake, ratios, and formulation of dietary GLA and EPA required to safely reduce leukotriene biosynthesis in healthy individuals, and to evaluate the pharmacokinetics and safety… CONTINUE READING