Inhibition of leukemic cell growth by a novel anti‐cancer drug (GUT‐70) from calophyllum brasiliense that acts by induction of apoptosis

@article{Kimura2005InhibitionOL,
  title={Inhibition of leukemic cell growth by a novel anti‐cancer drug (GUT‐70) from calophyllum brasiliense that acts by induction of apoptosis},
  author={S. Kimura and C. Ito and N. Jyoko and H. Segawa and J. Kuroda and M. Okada and S. Adachi and T. Nakahata and T. Yuasa and V. C. Filho and H. Furukawa and T. Maekawa},
  journal={International Journal of Cancer},
  year={2005},
  volume={113}
}
During our search for cancer chemopreventing compounds derived from plant sources, we discovered that the natural product GUT‐70, isolated from the stem bark of Calophyllum brasiliense collected in Brazil, significantly inhibits the growth of leukemic cells. GUT‐70, characterized as a tricyclic coumarin, 5‐methoxy‐2,2‐dimethyl‐6‐(2‐methyl‐1‐oxo‐2‐butenyl) ‐10‐propyl‐2H,8H‐benzo[1,2‐b;3,4‐b′]dipyran‐8‐one (C23H26O5), inhibited all 6 human leukemic cell lines evaluated, including the P… Expand
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References

SHOWING 1-10 OF 54 REFERENCES
Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum.
A pro-apoptotic effect of the CDK inhibitor p57(Kip2) on staurosporine-induced apoptosis in HeLa cells.
...
1
2
3
4
5
...