Inhibition of lectin-mediated innate host defences in vivo modulates disease severity during influenza virus infection.

@article{Tate2011InhibitionOL,
  title={Inhibition of lectin-mediated innate host defences in vivo modulates disease severity during influenza virus infection.},
  author={Michelle D Tate and Andrew G. Brooks and Patrick C. Reading},
  journal={Immunology and cell biology},
  year={2011},
  volume={89 3},
  pages={
          482-91
        }
}
Host-mediated recognition of mannose-rich glycans on the surface of pathogens represents an ancient mechanism of innate immune defence. In this study, we demonstrate that the virus strains that differ in the degree of N-linked glycosylation on the globular head of their hemagglutinin glycoprotein also differed in their (i) sensitivity to neutralization by a mannose-specific lectin in mouse lung fluids and (ii) ability to infect (and, therefore, to be destroyed) by airway macrophages. Virus… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…