Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis

@article{Fujita2006InhibitionOL,
  title={Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis},
  author={Manabu Fujita and Natalya M. Khazenzon and Alexander V Ljubimov and Bong-Seop Lee and Ismo Virtanen and Eggehard Holler and Keith L. Black and Julia Y. Ljubimova},
  journal={Angiogenesis},
  year={2006},
  volume={9},
  pages={183-191}
}
We have previously shown that laminin-8, a vascular basement membrane component, was overexpressed in human glioblastomas multiforme and their adjacent tissues compared to normal brain. Increased laminin-8 correlated with shorter glioblastoma recurrence time and poor patient survival making it a potential marker for glioblastoma diagnostics and prediction of disease outcome. However, laminin-8 therapeutic potential was unknown because the technology of blocking the expression of multi-chain… CONTINUE READING
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