Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis
@article{Fujita2006InhibitionOL, title={Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis}, author={Manabu Fujita and Natalya M. Khazenzon and Alexander V. Ljubimov and Bong-Seop Lee and Ismo Virtanen and Eggehard Holler and Keith L. Black and Julia Y. Ljubimova}, journal={Angiogenesis}, year={2006}, volume={9}, pages={183-191} }
We have previously shown that laminin-8, a vascular basement membrane component, was overexpressed in human glioblastomas multiforme and their adjacent tissues compared to normal brain. Increased laminin-8 correlated with shorter glioblastoma recurrence time and poor patient survival making it a potential marker for glioblastoma diagnostics and prediction of disease outcome. However, laminin-8 therapeutic potential was unknown because the technology of blocking the expression of multi-chain…
55 Citations
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References
SHOWING 1-10 OF 38 REFERENCES
Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro.
- BiologyMolecular cancer therapeutics
- 2003
The results show that laminin-8 may contribute to glioma progression and recurrence not only as part of the neovascularization process but also by directly increasing the invasive potential of tumor cells.
Overexpression of β1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases
- MedicineBreast Cancer Research
- 2004
Similar to high-grade brain gliomas, the expression of laminin-8 (and lamin in-10) in breast cancer tissue may be a predictive factor for tumor neovascularization and invasion and suggest that laminationin-2, laminine-8, and laminIn-10 are important components of tumor microvessels and may associate with breast tumor progression.
Antiangiogenic Drugs Synergize with a Membrane Macrophage Colony-Stimulating Factor-Based Tumor Vaccine to Therapeutically Treat Rats with an Established Malignant Intracranial Glioma1
- Biology, MedicineThe Journal of Immunology
- 2005
Animals that rejected the established T9/9L glioma by the combination therapy proved immune against an intracranial rechallenge by T9/, but showed no resistance to an unrelated MADB106 breast cancer.
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470
- Biology, ChemistryNature Medicine
- 2004
A water-soluble conjugate of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer, Gly-Phe-Leu-Gly linker and T NP-470 substantially enhanced and prolonged the activity of TNP-470 in vivo in tumor and hepatectomy models.
Intravenous RNA Interference Gene Therapy Targeting the Human Epidermal Growth Factor Receptor Prolongs Survival in Intracranial Brain Cancer
- Biology, MedicineClinical Cancer Research
- 2004
Purpose: The human epidermal growth factor receptor (EGFR) plays an oncogenic role in solid cancer, including brain cancer. The present study was designed to prolong survival in mice with…
Polycefin, a new prototype of a multifunctional nanoconjugate based on poly(beta-L-malic acid) for drug delivery.
- Biology, ChemistryBioconjugate chemistry
- 2006
In vitro experiments using two human glioma cell lines U87MG and T98G demonstrated that Polycefin was delivered into the tumor cells by a receptor-mediated endocytosis mechanism and was able to inhibit the synthesis of laminin-8 alpha4 and beta1 chains at the same time.
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
- Biology, MedicineNature Medicine
- 2002
Smac agonists are promising candidates for cancer therapy by potentiating cytotoxic therapies by enhancing the antitumor activity of Apo-2L/tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) in an intracranial malignant glioma xenograft model in vivo.
Localization of c-Myb and Induction of Apoptosis by Antisense Oligonucleotide c-myb After Angioplasty of Porcine Coronary Arteries
- Biology, MedicineArteriosclerosis, thrombosis, and vascular biology
- 2001
Previous studies have shown that inhibition of the proto-oncogene c-myb inhibits neointimal formation in various animal models. However, the temporal and spatial expression of c-Myb in the vessel…
Association between laminin‐8 and glial tumor grade, recurrence, and patient survival
- MedicineCancer
- 2004
One of these laminins, laminin‐8, was found to be present in highly invasive and malignant glioblastoma multiforme (GBM) (Grade 4 astrocytoma); its expression was associated with a decreased time to tumor recurrence, and it was found in vitro to promote invasion of GBM cell lines.
HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer.
- BiologyAdvances in experimental medicine and biology
- 2003
The authors' studies document a unique and unexpected advantage of the combination of HPMA copolymer bound doxorubicin with mesochlorin e6/photodynamic therapy in the treatment of ovarian cancer, and predict an exciting future for this novel drug delivery system.