Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis

@article{Fujita2006InhibitionOL,
  title={Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis},
  author={Manabu Fujita and Natalya M. Khazenzon and Alexander V. Ljubimov and Bong-Seop Lee and Ismo Virtanen and Eggehard Holler and Keith L. Black and Julia Y. Ljubimova},
  journal={Angiogenesis},
  year={2006},
  volume={9},
  pages={183-191}
}
We have previously shown that laminin-8, a vascular basement membrane component, was overexpressed in human glioblastomas multiforme and their adjacent tissues compared to normal brain. Increased laminin-8 correlated with shorter glioblastoma recurrence time and poor patient survival making it a potential marker for glioblastoma diagnostics and prediction of disease outcome. However, laminin-8 therapeutic potential was unknown because the technology of blocking the expression of multi-chain… 
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References

SHOWING 1-10 OF 38 REFERENCES
Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro.
TLDR
The results show that laminin-8 may contribute to glioma progression and recurrence not only as part of the neovascularization process but also by directly increasing the invasive potential of tumor cells.
Overexpression of β1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases
TLDR
Similar to high-grade brain gliomas, the expression of laminin-8 (and lamin in-10) in breast cancer tissue may be a predictive factor for tumor neovascularization and invasion and suggest that laminationin-2, laminine-8, and laminIn-10 are important components of tumor microvessels and may associate with breast tumor progression.
Antiangiogenic Drugs Synergize with a Membrane Macrophage Colony-Stimulating Factor-Based Tumor Vaccine to Therapeutically Treat Rats with an Established Malignant Intracranial Glioma1
TLDR
Animals that rejected the established T9/9L glioma by the combination therapy proved immune against an intracranial rechallenge by T9/, but showed no resistance to an unrelated MADB106 breast cancer.
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470
TLDR
A water-soluble conjugate of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer, Gly-Phe-Leu-Gly linker and T NP-470 substantially enhanced and prolonged the activity of TNP-470 in vivo in tumor and hepatectomy models.
Intravenous RNA Interference Gene Therapy Targeting the Human Epidermal Growth Factor Receptor Prolongs Survival in Intracranial Brain Cancer
Purpose: The human epidermal growth factor receptor (EGFR) plays an oncogenic role in solid cancer, including brain cancer. The present study was designed to prolong survival in mice with
Polycefin, a new prototype of a multifunctional nanoconjugate based on poly(beta-L-malic acid) for drug delivery.
TLDR
In vitro experiments using two human glioma cell lines U87MG and T98G demonstrated that Polycefin was delivered into the tumor cells by a receptor-mediated endocytosis mechanism and was able to inhibit the synthesis of laminin-8 alpha4 and beta1 chains at the same time.
Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
TLDR
Smac agonists are promising candidates for cancer therapy by potentiating cytotoxic therapies by enhancing the antitumor activity of Apo-2L/tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) in an intracranial malignant glioma xenograft model in vivo.
Localization of c-Myb and Induction of Apoptosis by Antisense Oligonucleotide c-myb After Angioplasty of Porcine Coronary Arteries
Previous studies have shown that inhibition of the proto-oncogene c-myb inhibits neointimal formation in various animal models. However, the temporal and spatial expression of c-Myb in the vessel
Association between laminin‐8 and glial tumor grade, recurrence, and patient survival
TLDR
One of these laminins, laminin‐8, was found to be present in highly invasive and malignant glioblastoma multiforme (GBM) (Grade 4 astrocytoma); its expression was associated with a decreased time to tumor recurrence, and it was found in vitro to promote invasion of GBM cell lines.
HPMA copolymer delivery of chemotherapy and photodynamic therapy in ovarian cancer.
TLDR
The authors' studies document a unique and unexpected advantage of the combination of HPMA copolymer bound doxorubicin with mesochlorin e6/photodynamic therapy in the treatment of ovarian cancer, and predict an exciting future for this novel drug delivery system.
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