Inhibition of keratinocyte proliferation by extracts of Actinobacillus actinomycetemcomitans.

@article{Kamen1983InhibitionOK,
  title={Inhibition of keratinocyte proliferation by extracts of Actinobacillus actinomycetemcomitans.},
  author={Paul R. Kamen},
  journal={Infection and immunity},
  year={1983},
  volume={42 3},
  pages={
          1191-4
        }
}
A heat-labile sonic extract of a nonleukotoxic strain of Actinobacillus actinomycetemcomitans caused a dose-dependent inhibition of proliferation of human keratinocytes. Exposure of cells to heat-labile sonic extract for periods as brief as 10 min produced significant suppression of [3H]thymidine uptake 72 h later. I propose that alteration of epithelial barriers may be one pathogenic mechanism of this organism. 

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