Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells.

@article{PrezSala1994InhibitionOI,
  title={Inhibition of isoprenoid biosynthesis induces apoptosis in human promyelocytic HL-60 cells.},
  author={Dolores P{\'e}rez-Sala and Faustino Mollinedo},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={199 3},
  pages={
          1209-15
        }
}
Protein isoprenylation is a posttranslational modification that facilitates membrane association and biological activity of a number of proteins. Mevalonate is the precursor of cellular sterols as well as of isoprenoid lipids involved in protein modification. In this study we show that HL-60 cells treated with lovastatin, an inhibitor of mevalonate synthesis, exhibit alterations in growth and morphology, as well as changes in the subcellular distribution of isoprenylated proteins like nuclear… CONTINUE READING
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