Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions.

@article{Porat2004InhibitionOI,
  title={Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions.},
  author={Yair Porat and Yariv Mazor and Shimon Efrat and Ehud Gazit},
  journal={Biochemistry},
  year={2004},
  volume={43 45},
  pages={14454-62}
}
The formation of amyloid fibril is associated with major human diseases, including Alzheimer's disease, prion diseases, and type 2 diabetes. Methods for efficient inhibition of amyloid fibril formation are therefore highly clinically important. A principal approach for the inhibition of amyloid formation is based on the use of modified molecular recognition elements. Here, we demonstrate efficient inhibition of amyloid formation of the type 2 diabetes-related human islet amyloid polypeptide… CONTINUE READING

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