Inhibition of ion transport in Ehrlich cells by muzolimine

  title={Inhibition of ion transport in Ehrlich cells by muzolimine},
  author={Peter Geck and Barbara Pfeiffer},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
The influence of muzolimine on the transport of Na+, K+ and Cl− was studied in Ehrlich cells to test whether the diuretic inhibits the furosemide-sensitive Na+−K+−2Cl−-cotransport or transport via the ouabain-sensitive Na+/K+-pump. It was shown that between 10−5 M and 10−3 M muzolimine pump-flux decreases with increasing drug concentration (IC50 about 0.5… CONTINUE READING